After his screen debut as Patrice Chéreau's "L'Homme blessé," Jean-Hugues Anglade appeared alongside Michel Piccoli in Richard Dembo's "Dangerous Moves". Luc Besson then offered him the part of the Roller in "Subway." Then came Zorg in Jean-Jacques Beineix's "Betty Blue". Among other awards, the film won the top prize at the Montreal Festival, competed for the Best Foreign Film Oscar and brought Jean-Hugues Anglade a best Actor César nomination. After starring alongside Nastassja Kinski in Jacques Deray's "Maladie d’amour," he acted for the first time in English in Alain Corneau's "Nocturne Indien" (Best Actor César nomination). This was followed by Luc Besson's "Nikita", Michel Deville's "One Summer Night in Town," Arnaud Sélignac's "Gawin," Roberto Faenza's "Années d’enfance" (winner of three David di Donatello awards in Italy), Roger Avary's "Killing Zoé" (winner at the Ubary Festival in Japan), and Elie Chouraqui's "les Marmottes". Shortly afterwards, he appeared in Patrice Chéreau's "Queen Margot" and won the Best Supporting Actor César for his performance as Charles IX. Alexandre Arcady is the first director to offer him a comic role in "Dis-moi oui".